There are many NMN products on the market, and it can be hard to choose the right one. It's important to do your research and find a product that is backed by science and that has a good reputation. You should also make sure that the product you choose is made with high-quality ingredients and that it has been third-party tested.
This article will try to give you a detailed explanation of everything you need to know before choosing an NMM product.
Is NMN safe to take?
This should be our main priority when it comes to dietary supplements.
This question actually raises two concerns: whether NMN has side effects and whether commercialized NMN products have potential safety hazards.
What are the side effects of NMN?
After a long-term experiment of feeding NMN in mice, as well as the NMN human clinical trials started in recent years, no side effects have been found. Harvard professor David Sinclair once mentioned in an interview that he would take 1000mg NMN a day and occasionally feel an upset stomach. Professor Imai of the University of Washington mentioned that according to the current human clinical trial reports, 300mg to 500mg of NMN per day has not found any side effects.
*The aforementioned information only applies to pure NMN (nicotinamide mononucleotide), not to NMN dietary supplement products that might also contain other ingredients.
What are the possible security risks of NMM products?
The Structure of NMN
β-Nicotinamide mononucleotide (β-NMN) is naturally present in the human body and has been confirmed to have no side effects, but α-nicotinamide mononucleotide (α-NMN) has the same structure as β-NMN, but the structure is completely opposite. α-NMN is a synthetic product that has not been found in the human body, and the toxic and side effects are not yet clear.
Please make sure the NMN product you are taking is β-Nicotinamide mononucleotide.
Manufacturing method and impurities
At present, there are three main methods of making NMN:
Chemical synthesis: Although NMN can be produced efficiently and cost-effectively, impurities exist in large quantities, and these impurities may cause unknown harm to the body.‘
Enzymatic synthesis: most products on the market are made for this method. This method can greatly eliminate impurities to obtain NMN with higher purity, and the yield is higher, but it cannot ensure that all the NMN produced is β-NMN.
Fermented biosynthesis: This method guarantees very high purity and all β-NMN produced, but the yield is very low.
So please make sure that the NMN product you take uses the fermented biosynthesis method.
Capsules that carry NMN
The location where NMN is most efficiently absorbed is the small intestine, and the capsule's job is to successfully transport NMN to the small intestine and release NMN. Before that, it needs to resist the saliva of the mouth and the strong acid of the stomach.
A capsule that cannot resist stomach acid will dissolve before reaching the small intestine, and NMN will not be able to achieve maximum absorption efficiency.
Make sure that the NMN product you take uses an acid-resistant capsule.
Substandard manufacturing environments, non-compliant operations will increase the risk of product mixing with impurities.
Please make sure that the manufacturing plant of the NMN product you are taking is GMP certified (quality management certified to reach medical level).
Is NMN valuable to take?
Does the chosen NMN product have a perceivable effect?
In addition to safety, we are even more concerned about whether the NMN taken has a significant effect. The obvious effect is of great benefit to us. It will give us positive feedback, so that we can pay more attention to our own changes and adopt more healthy behaviors. Conversely, nutritional supplements with no apparent feelings are just a burden that makes it hard to stick to them and doesn't encourage us to do more behaviors that benefit our health.
There are many factors that affect the effect, manufacturing environment, manufacturing location, manufacturing method, raw materials, purity of core ingredients, capsules, etc. At present, most NMN products on the market have achieved high purity, and the manufacturing method and raw materials are the most important factors affecting the effect. Yeast fermentation (Fermented biosynthesis) is currently the highest purity and best quality manufacturing method. The world's first human clinical trial of NMN conducted by Professor Imai from the University of Washington also used NMN prepared by yeast fermentation.
If you want to take NMN products with visible effects, choose products made using yeast fermentation methods.
Is the chosen NMM product endorsed by professionals in this field?
Since most of the research on NMN is still in the experimental stage, with each new discovery NMN product manufacturers need to update the product's manufacturing method, environment, and information in a timely manner. Therefore, a manufacturer that continues to work closely with leading experts in the field of anti-aging is worth watching.
Has the chosen NMM product gotten positive reviews from customers?
Everyone's physique is different, not an NMN product that works for others will necessarily work for you. When choosing, please try to understand the feedback of other users as much as possible, whether most users have obvious effects.